The first trucks fitted with autonomous haulage technology (AHS) are now in operation at Christmas Creek.
It's part of a program to convert 100 trucks to autonomous operations within three years, which is set to help the company achieve its C1 cost guidance of US$11-12 per wet metric tonne.
The cost of the program is included in FMG's full-year sustaining capital guidance of $3/t.
FMG said that since the introduction of AHS at Solomon in 2013, the trucks had moved over half a billion tonnes of material and achieved a greater than 30% increase in productivity.
FMG CEO Elizabeth Gaines said the company would continue to embrace cutting-edge technology to ensure it remained at the lower end of the global iron ore cost curve.
"Innovation and technology is fundamental to driving sustained productivity and efficiency improvements across the business, ensuring we continue to deliver returns for our shareholders and key stakeholders," she said.
"Most importantly, the introduction of AHS technology is leading to improved safety outcomes by significantly reducing the risk to our team members."
FMG also has 10 autonomous drills in operation and is trialling a relocatable conveyer at Cloubbreak to lower haulage costs to offset rising strip ratios.
Like the other big Pilbara miners, FMG is working on redeploying members of its workforce impacted by automation.
"Training is at the heart of everything that we do and our approach to autonomy is to ensure that no one at Fortescue is displaced as a result of this important initiative," Gaines said.
"We are working closely with our team members to offer professional development opportunities to expand their capabilities and provide pathways to a significant range of different roles throughout the company."